- R -
- Rappaport classification system for lymphoma (also modified Rappaport classification system) (I-IV)
- REAL (Revised European American classification of Lymphoid neoplasms) B-cell, T-cell, and Hodgkin (now known as B-cell)
- Ringertz grading system for glial tumors (astrocytoma, anaplastic astrocytoma, and glioblastoma multiforme) I-IV
- Robson staging system for renal cell carcinoma (I-IV)
- RTOG (Radiation Therapy Oncology Group) classification system for DCIS (stage II-IV, phase I-III, grade 1-5)
- Russell classification system for soft tissue sarcomas (grade 1-4) as a G1-4 prefix to TNM
- Rye classification system for Hodgkin disease (0-IV)
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