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• Cancer Drugs

- Z -

• Z-360

A selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells.



• Zactima

(Other name for: ZD6474)



• Zanosar

(Other name for: streptozocin)



• Zarnestra

(Other name for: tipifarnib)



• ZD4054

An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. ZD4054 binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation.



• ZD6474

An orally bioavailable 4-anilinoquinazoline. ZD-6474 selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.



• Zemplar

(Other name for: paricalcitol)



• Zenapax

(Other name for: daclizumab)



• Zevalin

(Other name for: yttrium Y 90 ibritumomab tiuxetan)



• zidovudine

A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines.



• zileuton

A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma.



• zinc sulfate

A salt of the essential trace metal zinc. Zinc is involved in tissue repair and is an important constituent of some proteins, including those involved in taste and smell. Zinc sulfate supplementation may prevent radiation-induced aguesia.



• Zinecard

(Other name for: dexrazoxane hydrochloride)



• Zocor

(Other name for: simvastatin)



• Zofran

(Other name for: ondansetron)



• Zoladex

(Other name for: goserelin)



• zoledronate

The brand name for zoledronic acid, a bisphosphonic imidazol compound which inhibits osteoclastic bone resorption. Although its mechanisms of action is yet to be fully characterized, zoledronic acid appears to directly inhibit osteoclast function and trigger osteoclast apoptotic cell death, thereby decreasing the osteoclast stimulation and bone calcium loss induced by various tumor-associated cytokines.



• Zolinza

(Other name for: vorinostat)



• Zoloft

(Other name for: sertraline)



• zolpidem tartrate

The tartrate salt of a non-benzodiazepine of the imidazopyridine class with sedative-hypnotic activity. Zolpidem binds to the omega-1 subclass of the gamma-aminobutyric acid type A (GABA-A ) receptor-chloride ionophore complex, thereby opening the chloride channel and resulting in hyperpolarization and inhibition of neuronal firing.



• Zometa

(Other name for: zoledronate)



• zosuquidar trihydrochloride

A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents.



• Zyban

(Other name for: bupropion hydrochloride)



• Zyflo

(Other name for: zileuton)



• Zyloprim

(Other name for: allopurinol)



• Zyprexa

(Other name for: olanzapine)