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- D -

• D gene

A small segment of immunoglobulin heavy-chain and T-cell receptor DNA, coding for the third hypervariable region of most receptors.



• Delayed type hypersensitivity (DTH)

A T cell-mediated reaction to antigen, which takes 24-48 hours to develop fully, and which involves release of lymphokines and recruitment of monocytes and macrophages. Also called c cell-mediated immunity.



• Determinant

Part of the antigen molecule which binds to an antibody-combining site or to a receptor on T cells (see hapten and epitope).



• Differentiation antigen

A cell surface antigenic determinant found only on cells of a certain lineage and at a particular developmental stage; used as an immunologic marker.



• Domain

A compact segment of an immunoglobulin molecule, made up of about 110 amino acids around an S-S bond, and encoded by a unique segment of DNA, surrounded by nontranslated sequences.



• DR antigens

MHC class II molecules found on B cells and antigen-presenting cells of humans.